糖尿病大鼠胃黏膜对吲哚美辛致溃疡作用的高敏感性。
High sensitivity of gastric mucosa to ulcerogenic effect of indomethacin in rats with diabetes.
作者信息
Podvigina T T, Bagaeva T R, Bobryshev P Yu, Filaretova L P
机构信息
Laboratory of Experimental Endocrinology, I. P. Pavlov Institute of Physiology, the Russian Academy of Sciences, St. Petersburg, Russia.
出版信息
Bull Exp Biol Med. 2011 Nov;152(1):43-6. doi: 10.1007/s10517-011-1449-y.
One week after injection of streptozotocin (60 mg/kg intravenously), rats developed diabetes associated with a significant increase of gastric mucosa sensitivity to the ulcerogenic effect of indomethacin (35 mg/kg subcutaneously). Since potentiation of the ulcerogenic effect of indomethacin was observed only in rats subjected to fasting before drug injection, we hypothesize that this effect was caused by a drop of high glucose level in the blood after fasting.
静脉注射链脲佐菌素（60毫克/千克）一周后，大鼠患上糖尿病，同时胃黏膜对消炎痛（35毫克/千克皮下注射）致溃疡作用的敏感性显著增加。由于仅在注射药物前禁食的大鼠中观察到消炎痛致溃疡作用增强，我们推测这种作用是由禁食后血糖水平大幅下降所致。
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