Kushnareva E Yu, Krupina N A, Khlebnikova N N, Zolotov N N, Kryzhanovskii G N
Laboratory for General Pathophysiology of Nervous System, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
Bull Exp Biol Med. 2011 Oct;151(6):675-9. doi: 10.1007/s10517-011-1413-x.
We studied the dynamics of activity of dipeptidyl peptidase IV (DP-IV) and prolyl endopeptidase (PEP) in the frontal cortex, hypothalamus, striatum, nucleus accumbens, and hippocampus of rats with experimental anxiety-depression state induced by administration of methionyl-2(s)-cyano-pyrrolidine, an inhibitor of DPP-IV, in the early postnatal period. In 1-month-old experimental males, PEP and DP-IV activities increased in the frontal cortex and hypothalamus, while in 1-month-old experimental females PEP activity increased in the hippocampus and DP-IV activity increased in all studied brain structures. At the age of 3 months, increased PEP activity in the hypothalamus and nucleus accumbens was detected in males and decreased DP-IV activity in the nucleus accumbens and decreased PEP activity in the hippocampus were detected in females. At the age of 7 months, PEP activity increased in the frontal cortex and striatum and DP-IV activity increased in all studied brain structures in males; in 7-months-old females, activity of both enzymes increased in the striatum.
我们研究了在出生后早期通过给予二肽基肽酶IV（DPP-IV）抑制剂甲硫氨酰-2（s）-氰基吡咯烷诱导实验性焦虑抑郁状态的大鼠的额叶皮质、下丘脑、纹状体、伏隔核和海马中，二肽基肽酶IV（DP-IV）和脯氨酰内肽酶（PEP）的活性动态变化。在1月龄的实验雄性大鼠中，额叶皮质和下丘脑的PEP和DP-IV活性增加，而在1月龄的实验雌性大鼠中，海马中的PEP活性增加，并且在所有研究的脑结构中DP-IV活性均增加。在3月龄时，雄性大鼠下丘脑和伏隔核中的PEP活性增加，雌性大鼠伏隔核中的DP-IV活性降低，海马中的PEP活性降低。在7月龄时，雄性大鼠额叶皮质和纹状体中的PEP活性增加，并且在所有研究的脑结构中DP-IV活性均增加；在7月龄的雌性大鼠中，纹状体中两种酶的活性均增加。
