Anikina T A, Anisimova I N, Sitdikov F G
Department of Human Anatomy and Physiology, Tatar State HumanitarianandTraining University, Kazan, Russia.
Bull Exp Biol Med. 2012 Apr;152(6):672-4. doi: 10.1007/s10517-012-1603-1.
We studied the effect of uridine 5'-triphosphate in concentrations of 10(-10)-10(-6) M on myocardial contractile activity in 7-100-day-old rats. Analysis of isometric contraction of myocardial strips showed that uridine 5'-triphosphate reduced the strength of myocardial contraction in rats of all age groups. In 21- and 100-day-old rat pups, exogenous uridine 5'-triphosphate produced a stronger inhibitory effect than in 7-day-old animals. The negative inotropic effect of UTP was abolished under conditions of P2Y(4) purinoceptor blockade with reagent blue-2. These data indicate that the effect of UTP on the myocardium is realized via P2Y(4) purinoceptors.
我们研究了浓度为10⁻¹⁰ - 10⁻⁶ M的尿苷5'-三磷酸对7 - 100日龄大鼠心肌收缩活性的影响。对心肌条的等长收缩分析表明，尿苷5'-三磷酸降低了所有年龄组大鼠的心肌收缩强度。在21日龄和100日龄的幼鼠中，外源性尿苷5'-三磷酸产生的抑制作用比7日龄动物更强。在用试剂蓝-2阻断P2Y(4)嘌呤受体的条件下，UTP的负性肌力作用被消除。这些数据表明，UTP对心肌的作用是通过P2Y(4)嘌呤受体实现的。
