Department of Chemistry, Bahauddin Zakariya University , Multan , Pakistan.
J Enzyme Inhib Med Chem. 2013 Oct;28(5):944-53. doi: 10.3109/14756366.2012.696246. Epub 2012 Jul 18.
A new series of four biologically active triazole derived Schiff base ligands (L(1)-L(4)) and their cobalt(II), nickel(II), copper(II) and zinc(II) complexes (1-16) have been synthesized and characterized. The ligands were prepared by the condensation reaction of 3-amino-5-methylthio-1H-1,2,4-triazole with chloro-, bromo- and nitro-substituted 2-hydroxybenzaldehyde in an equimolar ratio. The antibacterial and antifungal bioactivity data showed the metal(II) complexes to be more potent antibacterial and antifungal than the parent Schiff bases against one or more bacterial and fungal species.
合成并表征了一系列四种具有生物活性的三唑衍生希夫碱配体（L(1)-L(4)）及其钴(II)、镍(II)、铜(II)和锌(II)配合物（1-16）。配体是通过 3-氨基-5-甲基硫代-1H-1,2,4-三唑与等摩尔比的氯代、溴代和硝基取代的 2-羟基苯甲醛缩合反应制备的。抗菌和抗真菌生物活性数据表明，与母体希夫碱相比，金属（II）配合物对一种或多种细菌和真菌具有更强的抗菌和抗真菌活性。
