Wójcik Oktawia P, Kjelsø Charlotte, Kuhn Katrin G, Müller Luise, Jensen Tenna, Kjeldsen Marianne K, Ethelberg Steen
European Programme for Intervention Epidemiology Training-EPIET, European Centre for Disease Prevention and Control, Stockholm, Sweden.
Scand J Infect Dis. 2012 Dec;44(12):903-8. doi: 10.3109/00365548.2012.693196. Epub 2012 Jul 17.
An outbreak of salmonellosis (Salmonella Typhimurium, phage type DT120) occurred from 26 January to 15 March 2011, in Denmark, with 22 laboratory confirmed cases. Hypothesis-generating patient interviews gave rise to the suspicion that smoked pork tenderloin was the source of infection. The primary objective of this study was to identify the source of the outbreak in order to initiate appropriate control measures.
A matched (1:2) case-control study was conducted. A case was defined as a person residing in Denmark whose stool sample tested positive for S. Typhimurium, with a particular multilocus variable-number tandem repeat profile, from January to March 2011. Controls were matched to cases on age, gender, and municipality of residence.
Of 21 interviewed cases, 19 (91%) indicated that they typically ate smoked pork tenderloin more than once a week, compared with 13 (33%) of 39 interviewed controls (matched odds ratio 19.6, 95% confidence interval 2.6-153). Eighteen (86%) cases indicated that they might have consumed smoked pork tenderloin the week before becoming ill, compared with 1 (4%) control who had eaten the product a week before the interview. Two cases provided the brand name of the product and the supermarket where it was purchased.
The results show a strong statistically significant association between the consumption of smoked pork tenderloin and S. Typhimurium infection. The European Rapid Alert System for Food and Feed was used to notify these findings to the competent authorities in the country of origin of the product. Subsequently, the smoked pork tenderloin of the brand in question, dating from 1 January to 1 May 2011, was recalled from consumers.
2011年1月26日至3月15日，丹麦爆发了沙门氏菌病（鼠伤寒沙门氏菌，噬菌体分型DT120），有22例实验室确诊病例。通过对患者进行产生假设的访谈，怀疑烟熏猪里脊肉是感染源。本研究的主要目的是确定疫情爆发的源头，以便采取适当的控制措施。
开展了一项匹配（1:2）病例对照研究。病例定义为2011年1月至3月期间居住在丹麦、粪便样本经检测鼠伤寒沙门氏菌呈阳性且具有特定多位点可变数目串联重复序列谱的人。对照在年龄、性别和居住市镇方面与病例相匹配。
在接受访谈的21例病例中，19例（91%）表示他们通常每周食用烟熏猪里脊肉不止一次，而在接受访谈的39例对照中，有13例（33%）是这样（匹配优势比为19.6，95%置信区间为2.6 - 153）。18例（86%）病例表示他们在发病前一周可能食用过烟熏猪里脊肉，相比之下，1例（4%）对照在访谈前一周食用过该产品。2例病例提供了产品的品牌名称及购买该产品的超市。
结果显示，食用烟熏猪里脊肉与鼠伤寒沙门氏菌感染之间存在统计学上的强显著关联。利用欧洲食品和饲料快速预警系统将这些结果通报给了该产品原产国的主管当局。随后，召回了2011年1月1日至5月1日期间该品牌的烟熏猪里脊肉。
