Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA.
Annu Rev Cell Dev Biol. 2012;28:29-58. doi: 10.1146/annurev-cellbio-101011-155718. Epub 2012 Jul 9.
Cytokinesis, the final step in cell division, partitions the contents of a single cell into two. In animal cells, cytokinesis occurs through cortical remodeling orchestrated by the anaphase spindle. Cytokinesis relies on a tight interplay between signaling and cellular mechanics and has attracted the attention of both biologists and physicists for more than a century. In this review, we provide an overview of four topics in animal cell cytokinesis: (a) signaling between the anaphase spindle and cortex, (b) the mechanics of cortical remodeling, (c) abscission, and (d) regulation of cytokinesis by the cell cycle machinery. We report on recent progress in these areas and highlight some of the outstanding questions that these findings bring into focus.
有丝分裂是细胞分裂的最后一步，将一个细胞的内容物分成两个。在动物细胞中，有丝分裂通过由后期纺锤体协调的皮质重塑发生。细胞分裂依赖于信号转导和细胞力学之间的紧密相互作用，一个多世纪以来一直吸引着生物学家和物理学家的关注。在这篇综述中，我们概述了动物细胞有丝分裂的四个主题：（a）后期纺锤体与皮质之间的信号转导，（b）皮质重塑的力学，（c）胞质分裂，以及（d）细胞周期机制对胞质分裂的调节。我们报告了这些领域的最新进展，并强调了这些发现所关注的一些悬而未决的问题。
