Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612, USA.
Br J Dermatol. 2012 Dec;167(6):1215-23. doi: 10.1111/j.1365-2133.2012.11139.x. Epub 2012 Oct 5.
Port-wine stain (PWS) birthmarks are one class of benign congenital vascular malformation. Laser therapy is the most successful treatment modality of PWS. Unfortunately, this approach has limited efficacy, with only 10% of patients experiencing complete blanching of the PWS. To address this problem, several research groups have developed technologies and methods designed to study treatment outcome and improve treatment efficacy. This article reviews seven optical imaging techniques currently in use or under development to assess treatment efficacy, focusing on: reflectance spectrophotometers/tristimulus colorimeters; laser Doppler flowmetry and laser Doppler imaging; cross-polarized diffuse reflectance colour imaging system; reflectance confocal microscopy; optical coherence tomography; spatial frequency domain imaging; and laser speckle imaging.
葡萄酒色斑（PWS）胎记是一类良性先天性血管畸形。激光治疗是 PWS 最成功的治疗方式。遗憾的是，这种方法的疗效有限，只有 10%的患者 PWS 完全消退。为了解决这个问题，一些研究小组已经开发了旨在研究治疗效果和提高治疗效果的技术和方法。本文综述了目前用于评估治疗效果的七种光学成像技术，重点介绍：反射分光光度计/三刺激比色计；激光多普勒流量计和激光多普勒成像；交叉偏振漫反射彩色成像系统；反射共聚焦显微镜；光学相干断层扫描；空间频域成像；和激光散斑成像。
