Ning Jing, Wang Fang, Liu Shui-Qing, Zhang Ru-Zhi, Liu Dan-Min, Li Yan
Department of Dermatology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, People's Republic of China.
Department of Ultrasound in Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, People's Republic of China.
Clin Cosmet Investig Dermatol. 2024 May 21;17:1183-1191. doi: 10.2147/CCID.S459613. eCollection 2024.
Hematoporphyrin monomethyl ether (HMME) is a promising photosensitizer for photodynamic therapy (PDT) and has found wide application in the treatment of port-wine stains (PWS).
This study aims to observe and analyze the clinical efficacy and safety of HMME-PDT in the treatment of PWS patients. It also aims to evaluate the usefulness of color Doppler flow imaging (CDFI), an ultrasound technique for detecting blood flow in skin lesions, in assessing clinical efficacy.
Thirty-three patients with PWS underwent HMME-PDT at our dermatology outpatient clinic between January 2019 and March 2020. Data on patient demographics, lesion location, lesion type (pink, purple, nodular thickening), treatment frequency, and pre- and post-treatment images were collected and retrospectively analyzed. CDFI was performed on three patients.
All patients received intravenous HMME and underwent irradiation with 532 nm green LED light. Of these, 5 patients received 1 session of HMME-PDT, 14 received 2 sessions, 9 received 3 sessions and the remaining 5 patients received more than 3 sessions. Of the 33 patients, 9 were cured (27.27%), 10 showed improvement (30.30%), 11 experienced a reduction in symptoms (33.33%), and 3 showed no significant improvement (9.09%). Most patients reported local pain and oedema, and no systemic adverse effects were observed. Clinical efficacy correlated with lesion type and total number of treatment sessions. CDFI appears to be an excellent technique for assessing clinical efficacy.
HMME-PDT is a safe and effective method for the treatment of PWS. CDFI examination appears to be a promising assessment tool. However, further validation with larger sample sizes is warranted.
血卟啉单甲醚（HMME）是一种很有前景的光动力疗法（PDT）光敏剂，已在鲜红斑痣（PWS）的治疗中得到广泛应用。
本研究旨在观察和分析HMME-PDT治疗PWS患者的临床疗效和安全性。同时旨在评估彩色多普勒血流成像（CDFI）这一用于检测皮肤病变血流的超声技术在评估临床疗效方面的实用性。
2019年1月至2020年3月期间，33例PWS患者在我院皮肤科门诊接受了HMME-PDT治疗。收集患者人口统计学数据、病变部位、病变类型（粉色、紫色、结节性增厚）、治疗次数以及治疗前后的图像，并进行回顾性分析。对3例患者进行了CDFI检查。
所有患者均接受了静脉注射HMME，并接受了532 nm绿色LED光照射。其中，5例患者接受了1次HMME-PDT治疗，14例接受了2次，9例接受了3次，其余5例患者接受了3次以上治疗。33例患者中，9例治愈（27.27%），10例好转（30.30%），11例症状减轻（33.33%），3例无明显改善（9.09%）。大多数患者报告有局部疼痛和水肿，未观察到全身不良反应。临床疗效与病变类型和治疗总次数相关。CDFI似乎是评估临床疗效的一种优秀技术。
HMME-PDT是治疗PWS的一种安全有效的方法。CDFI检查似乎是一种很有前景的评估工具。然而，需要更大样本量的进一步验证。
