奥氏肽-1的生物活性，一种源自天然免疫调节剂奥氏肌动蛋白的合成肽。

Biological activity of obiopeptide-1, a synthetic peptide derived from the native immune-regulator obioactin.

作者信息

Suzuki N, Sakurai H, Saito A, Igarashi I, Omata Y, Osaki H

机构信息

Department of Veterinary Physiology and Protozoan Immunology, Obihiro University, Hokkaido, Japan.

出版信息

Nihon Juigaku Zasshi. 1990 Oct;52(5):907-14. doi: 10.1292/jvms1939.52.907.

DOI:10.1292/jvms1939.52.907

PMID:2280500

Abstract

Tachyzoites of Toxoplasma gondii were killed in mouse macrophage and human somatic cell monolayers by a novel synthetic peptide (Obiopeptide-1) which is a Glycil-penta-Glutaminate (GpG) derivative of native Obioactin. In view of the worldwide prevalence of this protozoan disease and the lack of effective treatments, Obiopeptide-1 may be a new and unique antimicrobial active substance of non-antibiotic chemotherapeutic agents for intracellular parasites, T. gondii and associated nonspecific hypoimmune responses that occur in infected hosts.

摘要

一种新型合成肽（Obiopeptide-1）可杀死小鼠巨噬细胞和人类体细胞单层中的刚地弓形虫速殖子，该肽是天然Obioactin的甘氨酰-五谷氨酸盐（GpG）衍生物。鉴于这种原生动物疾病在全球的流行以及缺乏有效的治疗方法，Obiopeptide-1可能是一种新型且独特的抗微生物活性物质，属于非抗生素化疗药物，可用于治疗细胞内寄生虫刚地弓形虫以及感染宿主中发生的相关非特异性免疫低下反应。