Suzuki N, Espinas F M, Sakurai H, Saito A, Sasaki H, Kato G, Manba K, Taniguchi K, Mochizuki K, Osaki H
Zentralbl Bakteriol Mikrobiol Hyg A. 1984 Mar;256(3):367-80.
In acutely infected mice, acetylspiramycin (ASPM) administered in combination with Obioactin , or sulfamethoxypyrazine ( SMPZ ), prevented Toxoplasma organisms from encysting in the brain and heart tissues. When administered alone, ASPM prevented these organisms from encysting in the heart but not in the brain. All the regimens used failed to reduce the bulk of parasites in the brain and heart tissues of chronically infected mice. Treatment with an ASPM- Obioactin combination, however, brought about the most remarkable reduction, or 52.4%, of the cyst count in the brain of all the methods of treatment applied. Light and electron microscopy of the mice with chronic Toxoplasma infection revealed no changes in the brain or heart tissue of the ASPM- Obioactin treated mice and degenerative changes in the cyst wall and bradyzoites and a remarkable increase of microglias with cysts in the brain in some of these mice.
在急性感染的小鼠中，乙酰螺旋霉素（ASPM）与奥硝唑（Obioactin）或磺胺甲氧嗪（SMPZ）联合使用，可防止弓形虫在脑和心脏组织中形成包囊。单独使用ASPM时，可防止这些生物体在心脏中形成包囊，但不能防止在脑中形成包囊。所有使用的治疗方案均未能减少慢性感染小鼠脑和心脏组织中的寄生虫数量。然而，在所有应用的治疗方法中，ASPM与奥硝唑联合治疗使脑中包囊数量减少最为显著，减少了52.4%。对慢性弓形虫感染小鼠的光镜和电镜检查显示，接受ASPM与奥硝唑治疗的小鼠脑和心脏组织无变化，部分小鼠的包囊壁和缓殖子有退行性变化，且脑中带有包囊的小胶质细胞显著增加。
