奥比阿廷的抗菌活性。

Antimicrobial activity of Obioactin.

作者信息

Osaki H, Furuya M, Nagasawa H, Suzuki N

出版信息

Zentralbl Bakteriol Mikrobiol Hyg A. 1984 Mar;256(3):328-34.

Abstract

A newly developed enzyme-hydrolyzed toxoplasma-hyperimmune bovine serum preparation, Obioactin , was examined for its anti-microbial and related actions against heterologous protozoa, bacteria, and viruses both in-vivo and in-vitro. An appreciable efficacy of Obioactin in a combination with nifurtimox, Lampit was observed in experimental Trypanosoma cruzi infections in mice. But prophylactic applications of the agent alone or joint with Lampit were in vain in mice. In-vitro digestion of certain bacteria in mouse peritoneal macrophages was accelerated in the presence of the agent being three to ten times stronger than that in untreated macrophages. Inhibitory effect of Obioactin on in-vitro infectivity of viruses was suggested.

摘要

一种新开发的酶水解弓形虫超免疫牛血清制剂Obioactin，在体内和体外对异源原生动物、细菌和病毒的抗菌及相关作用进行了研究。在小鼠实验性克氏锥虫感染中，观察到Obioactin与硝呋替莫（Lampit）联合使用具有显著疗效。但单独使用该制剂或与Lampit联合进行预防性应用在小鼠中均无效。在该制剂存在的情况下，小鼠腹腔巨噬细胞中某些细菌的体外消化加速，其效果比未处理的巨噬细胞强三到十倍。提示Obioactin对病毒的体外感染性有抑制作用。