Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine,1959 Pacific Ave, NE, Seattle, WA 98195 USA.
BMC Biol. 2012 Jul 17;10:61. doi: 10.1186/1741-7007-10-61.
Phosphorylation is the predominant language of cell signaling. And, as with any common language, an abundance of dialects has evolved to convey complex information. We discuss here how biosensors are being used to decode this language, affording an unprecedented glimpse into spatio-temporal patterns of protein phosphorylation events within the cell.
磷酸化是细胞信号转导的主要语言。而且，就像任何常见的语言一样，已经衍生出大量的方言来传达复杂的信息。在这里，我们讨论了生物传感器如何用于解码这种语言，从而可以以前所未有的方式洞察细胞内蛋白质磷酸化事件的时空模式。
