胰腺发生癌变过程中的分子通路。
Molecular pathways in pancreatic carcinogenesis.
机构信息
Pathobiology Program, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
出版信息
J Surg Oncol. 2013 Jan;107(1):8-14. doi: 10.1002/jso.23213. Epub 2012 Jul 17.
Abstract
Pancreatic cancer is a genetic disease. Pancreatic cancers develop from one of three precursor lesions, pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasms (IPMNs), and mucinous cystic neoplasms (MCNs), and each arises in association with distinct genetic alterations. These alterations not only provide insight into the fundamental origins of pancreatic cancer but provide ample opportunity for improving early diagnosis and management of cystic precursors.
摘要
胰腺癌是一种遗传性疾病。胰腺癌起源于三种前体病变之一，即胰腺上皮内瘤变（PanIN）、导管内乳头状黏液性肿瘤（IPMN）和黏液性囊腺瘤（MCN），每种病变都与特定的遗传改变有关。这些改变不仅深入了解了胰腺癌的根本起源，还为提高囊性前体的早期诊断和管理水平提供了充分的机会。
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