Rauner M, Hofbauer L C, Aringer M
Bereich Endokrinologie, Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Deutschland.
Z Rheumatol. 2012 Dec;71(10):869-73. doi: 10.1007/s00393-011-0927-y.
Rheumatoid arthritis (RA) is a bone-destructive disease that is a serious risk factor for the development of osteoporosis, which is defined by a loss in bone quality and an increased fracture risk. The proinflammatory cytokines tumor necrosis factor-α (TNFα), interleukin-6 (IL-6) and IL-17, in particular, contribute to local and systemic bone loss in RA. While effectively reducing inflammation, glucocorticoids add to the fracture risk. Therefore, an adequate supply of calcium and vitamin D is essential. For many patients with RA, bone density measurements are recommended.
类风湿性关节炎（RA）是一种具有骨质破坏作用的疾病，是骨质疏松症发生的严重风险因素，骨质疏松症的定义为骨质质量下降和骨折风险增加。特别是促炎细胞因子肿瘤坏死因子-α（TNFα）、白细胞介素-6（IL-6）和IL-17，在类风湿性关节炎中会导致局部和全身性骨质流失。糖皮质激素虽然能有效减轻炎症，但会增加骨折风险。因此，充足的钙和维生素D供应至关重要。对于许多类风湿性关节炎患者，建议进行骨密度测量。
