Levine Pascale, Fried Karen, Krevitt Lane D, Wang Beverly, Wenig Bruce M
Department of Pathology, NYU Cancer Institute, New York, New York.
Diagn Cytopathol. 2014 Jan;42(1):49-53. doi: 10.1002/dc.22886. Epub 2012 Jul 16.
Mammary analogue secretory carcinoma (MASC) is a newly described rare salivary gland tumor, which shares morphologic features with acinic cell carcinoma, low-grade cystadenocarcinoma, and secretory carcinoma of the breast. This is the first reported case of MASC of an accessory parotid gland detected by aspiration biopsy with radiologic and histologic correlation in a 34-year-old patient. Sonographically-guided aspiration biopsy showed cytologic features mimicking those of low-grade mucoepidermoid carcinoma, including sheets of bland epithelial cells, dissociated histiocytoid cells with intracytoplasmic mucinous material, and spindle cells lying in a web-like matrix. Histologic sections showed a circumscribed tumor with microcystic spaces lined by bland uniform epithelial cells and containing secretory material. The tumor cells expressed mammaglobin and BRST-2. The cytologic features, differential diagnosis, and pitfalls are discussed. The pathologic stage was pT1N0. The patient showed no evidence of disease at 1 year follow-up.
乳腺样分泌癌（MASC）是一种新描述的罕见唾液腺肿瘤，它与腺泡细胞癌、低级别囊腺癌以及乳腺分泌癌具有形态学特征。这是首例通过细针穿刺活检并结合放射学和组织学检查发现的副腮腺MASC病例，患者为一名34岁女性。超声引导下的细针穿刺活检显示细胞学特征类似低级别黏液表皮样癌，包括成片的温和上皮细胞、带有胞浆内黏液物质的散在组织细胞样细胞，以及位于网状基质中的梭形细胞。组织学切片显示肿瘤边界清晰，有微囊腔隙，内衬温和一致的上皮细胞并含有分泌物质。肿瘤细胞表达乳腺珠蛋白和BRST-2。文中讨论了细胞学特征、鉴别诊断及陷阱。病理分期为pT1N0。患者在1年随访中无疾病证据。
