Kim Seong Hwan, Hong Min Eui, Lee Dong Jin
Department of Plastic and Reconstructive Surgery.
Department of Pathology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
Medicine (Baltimore). 2020 Jul 10;99(28):e20218. doi: 10.1097/MD.0000000000020218.
Mammary analogue secretory carcinoma is a low grade salivary gland malignancy, first described by Skalova et al in 2010. The histological, immunohistochemical, and molecular characteristics of this tumor resemble those of secretory carcinoma of the breast.
A 40-year-old male patient without any specific past history came with complaints of 4 cm-sized hard, fixed, right infra-auricular mass without tenderness. There was no enlarged or enhancing lymph node in both neck.
Fine needle aspiration biopsy was done for right parotid mass and pathologic report was "lymphocytes only" that suggested benign or low-grade malignant parotid tumor.
Partial parotidectomy including mass excision was performed. Operative finding showed hard bluish mass located in deep lobe of right parotid gland.
Final pathologic report revealed secretory carcinoma of parotid gland. Homogenous eosinophilic secretions were identified inside microcystic structure. The immunophenotype was positive for epithelial membrane antigen, vimentin, S-100 protein. After 15 months of the surgery, the patient showed negative evidence of disease state.
We present here a case of mammary analogue secretory carcinoma of the parotid gland to help further characterize this rare tumor.
乳腺样分泌癌是一种低度恶性的涎腺肿瘤，于2010年由斯卡洛娃等人首次描述。该肿瘤的组织学、免疫组化及分子特征与乳腺分泌癌相似。
一名40岁男性患者，无特殊既往史，主诉右耳下有一4厘米大小的硬性、固定肿块，无压痛。双侧颈部无肿大或强化的淋巴结。
对右侧腮腺肿块进行了细针穿刺活检，病理报告为“仅见淋巴细胞”，提示腮腺肿瘤为良性或低度恶性。
实施了包括肿块切除的部分腮腺切除术。术中发现右侧腮腺深叶有一硬性蓝色肿块。
最终病理报告显示为腮腺分泌癌。在微囊结构内发现均匀的嗜酸性分泌物。免疫表型显示上皮膜抗原、波形蛋白、S-100蛋白呈阳性。手术后15个月，患者疾病状态呈阴性。
我们在此报告一例腮腺乳腺样分泌癌病例，以帮助进一步明确这种罕见肿瘤的特征。
