• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

腮腺分泌性癌中的NTRK3突变：一例报告。

NTRK3 mutation in secretory carcinoma of the parotid gland: A Case report.

作者信息

AlKaabba Fahad, Alloghbi Abdurahman, Deajim Yazeed, Sukkari Mohamad W, Khan Mir Yousufuddin Ali, Sukari Ammar

机构信息

Department of Medicine University of Maryland Medical Center Baltimore MD USA.

College of Medicine King Khalid University Abha Saudi Arabia.

出版信息

Clin Case Rep. 2022 Sep 5;10(9):e6243. doi: 10.1002/ccr3.6243. eCollection 2022 Sep.

DOI:10.1002/ccr3.6243
PMID:36093449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9445263/
Abstract

Mammary analog secretory carcinoma (MASC) is a newly described carcinoma with a molecular hallmark of ETV6-NTRK3 fusion that promotes oncogenesis. While MASC histopathology was well-studied in the literature, clinical behavior remains unstudied. We present a 22-year-old man with painless parotid mass, which was diagnosed as salivary gland cancer, MASC subtype.

摘要

乳腺样分泌癌（MASC）是一种新描述的癌，具有促进肿瘤发生的ETV6-NTRK3融合分子特征。虽然MASC的组织病理学在文献中有充分研究，但临床行为仍未得到研究。我们报告一名22岁男性，有无痛性腮腺肿块，被诊断为唾液腺癌，MASC亚型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bfb/9445263/4c2c80d1b744/CCR3-10-e6243-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bfb/9445263/c9eace9d1d83/CCR3-10-e6243-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bfb/9445263/4c2c80d1b744/CCR3-10-e6243-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bfb/9445263/c9eace9d1d83/CCR3-10-e6243-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bfb/9445263/4c2c80d1b744/CCR3-10-e6243-g002.jpg

相似文献

1
NTRK3 mutation in secretory carcinoma of the parotid gland: A Case report.腮腺分泌性癌中的NTRK3突变：一例报告。
Clin Case Rep. 2022 Sep 5;10(9):e6243. doi: 10.1002/ccr3.6243. eCollection 2022 Sep.
2
Mammary analogue secretory carcinoma of salivary glands: a clinicopathologic and molecular study including 2 cases harboring ETV6-X fusion.涎腺乳腺样分泌癌：一项临床病理及分子研究，包括2例携带ETV6-X融合基因的病例
Am J Surg Pathol. 2015 May;39(5):602-10. doi: 10.1097/PAS.0000000000000392.
3
Mammary analogue secretory carcinoma of salivary glands with high-grade transformation: report of 3 cases with the ETV6-NTRK3 gene fusion and analysis of TP53, β-catenin, EGFR, and CCND1 genes.唾液腺乳腺样分泌性癌伴高级别转化：3 例 ETV6-NTRK3 基因融合病例报告及 TP53、β-catenin、EGFR 和 CCND1 基因分析。
Am J Surg Pathol. 2014 Jan;38(1):23-33. doi: 10.1097/PAS.0000000000000088.
4
Molecular analysis of a mammary analog secretory carcinoma in the upper lip: Novel search for genetic and epigenetic abnormalities in MASC.上唇乳腺样分泌性癌的分子分析：对乳腺样分泌性癌基因和表观遗传异常的新探索
Int J Surg Case Rep. 2015;9:8-11. doi: 10.1016/j.ijscr.2015.02.011. Epub 2015 Feb 11.
5
Mammary Analog Secretory Carcinoma (MASC) Involving the Thyroid Gland: A Report of the First 3 Cases.累及甲状腺的乳腺样分泌性癌（MASC）：首例3例报告
Head Neck Pathol. 2017 Jun;11(2):124-130. doi: 10.1007/s12105-016-0741-6. Epub 2016 Jul 11.
6
ETV6-NTRK3-positive parotid mammary analogue secretory carcinoma: a case report.ETV6-NTRK3 阳性腮腺乳腺样分泌癌：一例报告。
Rom J Morphol Embryol. 2021 Jan-Mar;62(1):309-312. doi: 10.47162/RJME.62.1.34.
7
Mammary analog secretory carcinoma of salivary gland with high-grade histology arising in hard palate, report of a case and review of literature.硬腭发生的具有高级别组织学特征的涎腺乳腺样分泌癌：1例报告并文献复习
Int J Clin Exp Pathol. 2014 Dec 1;7(12):9008-22. eCollection 2014.
8
Mammary analog secretory carcinoma of the thyroid gland: A primary thyroid adenocarcinoma harboring ETV6-NTRK3 fusion.甲状腺乳腺样分泌癌：一种携带ETV6-NTRK3融合基因的原发性甲状腺腺癌。
Mod Pathol. 2016 Sep;29(9):985-95. doi: 10.1038/modpathol.2016.115. Epub 2016 Jun 10.
9
Characterization of mammary analogue secretory carcinoma of the salivary gland: discrimination from its mimics by the presence of the ETV6-NTRK3 translocation and novel surrogate markers.涎腺乳腺样分泌性癌的特征：通过ETV6-NTRK3易位的存在及新的替代标志物与相似肿瘤相鉴别
Hum Pathol. 2015 Jan;46(1):94-103. doi: 10.1016/j.humpath.2014.09.012. Epub 2014 Oct 7.
10
Expanding the Molecular Spectrum of Secretory Carcinoma of Salivary Glands With a Novel VIM-RET Fusion.扩展唾液腺癌的分子谱，发现一种新型的 VIM-RET 融合。
Am J Surg Pathol. 2020 Oct;44(10):1295-1307. doi: 10.1097/PAS.0000000000001535.

引用本文的文献

1
Diagnostic Utility of Expression Pattern of S100/Mammaglobin/SOX10/DOG 1 Immunohistochemistry in Differentiation of Secretory and Acinic Cell Carcinoma: A Systematic Review and Meta-Analysis.S100/乳腺珠蛋白/SOX10/DOG1免疫组化表达模式在分泌性癌和腺泡细胞癌鉴别诊断中的应用价值：一项系统评价和Meta分析
Indian J Otolaryngol Head Neck Surg. 2024 Feb;76(1):208-218. doi: 10.1007/s12070-023-04127-z. Epub 2023 Aug 14.

本文引用的文献

1
Parotid mammary analogue secretory carcinoma: A case report and review of literature.腮腺乳腺样分泌性癌：一例病例报告并文献复习
World J Clin Cases. 2021 Jun 6;9(16):4052-4062. doi: 10.12998/wjcc.v9.i16.4052.
2
Larotrectinib in patients with TRK fusion-positive solid tumours: a pooled analysis of three phase 1/2 clinical trials.拉罗替尼治疗 TRK 融合阳性实体瘤患者的疗效：三项 I/II 期临床试验的汇总分析。
Lancet Oncol. 2020 Apr;21(4):531-540. doi: 10.1016/S1470-2045(19)30856-3. Epub 2020 Feb 24.
3
Emerging Targeted Therapy for Tumors with Fusion Proteins.
融合蛋白肿瘤的新兴靶向治疗。
Clin Cancer Res. 2018 Dec 1;24(23):5807-5814. doi: 10.1158/1078-0432.CCR-18-1156. Epub 2018 Jul 9.
4
Clinicopathological characteristics and outcome of 31 patients with ETV6-NTRK3 fusion gene confirmed (mammary analogue) secretory carcinoma of salivary glands.31 例 ETV6-NTRK3 融合基因阳性（乳腺型）涎腺分泌型癌患者的临床病理特征和预后分析。
Oral Oncol. 2018 Jul;82:29-33. doi: 10.1016/j.oraloncology.2018.04.022. Epub 2018 May 11.
5
Cytological features of mammary analogue secretory carcinoma of the parotid gland in a 15-year-old girl: a case report with review of the literature.一名15岁女孩腮腺乳腺样分泌癌的细胞学特征：病例报告并文献复习
Case Rep Pathol. 2015;2015:656107. doi: 10.1155/2015/656107. Epub 2015 Mar 1.
6
Mammary analogue secretory carcinoma of salivary glands: a new entity associated with ETV6 gene rearrangement.涎腺乳腺样分泌癌：一种与ETV6基因重排相关的新实体。
Virchows Arch. 2015 Mar;466(3):245-54. doi: 10.1007/s00428-014-1701-8. Epub 2014 Dec 12.
7
Mammary analogue secretory carcinoma (MASC) of salivary gland in four Mexican patients.4例墨西哥患者的涎腺乳腺样分泌癌
Med Oral Patol Oral Cir Bucal. 2015 Jan 1;20(1):e23-9. doi: 10.4317/medoral.19874.
8
Mammary analogue secretory carcinoma: update on a new diagnosis of salivary gland malignancy.乳腺分泌型癌：涎腺恶性肿瘤的一种新诊断。
Laryngoscope. 2014 Jan;124(1):188-195. doi: 10.1002/lary.24254. Epub 2013 Jul 9.
9
Cytopathologic features of mammary analogue secretory carcinoma.乳腺分泌型癌的细胞病理学特征。
Cancer Cytopathol. 2013 May;121(5):228-33. doi: 10.1002/cncy.21245. Epub 2012 Oct 5.
10
Aspiration biopsy of mammary analogue secretory carcinoma of accessory parotid gland: another diagnostic dilemma in matrix-containing tumors of the salivary glands.腮腺副腺体乳腺样分泌癌的细针穿刺活检：涎腺含基质肿瘤中的另一个诊断难题。
Diagn Cytopathol. 2014 Jan;42(1):49-53. doi: 10.1002/dc.22886. Epub 2012 Jul 16.