Tojo Gen-Ichi, Fujimura Taku, Kambayashi Yumi, Kikuchi Katsuko, Aiba Setsuya
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Case Rep Dermatol. 2012 May;4(2):158-62. doi: 10.1159/000341196. Epub 2012 Jul 12.
We report the case of a 55-year-old Japanese patient with granuloma faciale (GF) successfully treated with topical tacrolimus and describe the immunohistochemical study. Immunohistochemical staining revealed that the patient's granuloma contained CD3(+), CD4(+), CD8(+), CD68(+) and CD163(+) cells. Interestingly, these cells contained granulysin(+) T cells and lacked Foxp3(high+) regulatory T cells. In addition, the macrophages were mainly CD163(+), which suggested that the alternatively activated macrophage is one of the main components of GF. In summary, the present data shed light on the granuloma-composing cells and possible mechanisms in the treatment of GF with topical tacrolimus.
我们报告了一例55岁的日本面部肉芽肿（GF）患者，其通过外用他克莫司成功治愈，并描述了免疫组织化学研究。免疫组织化学染色显示，该患者的肉芽肿含有CD3(+)、CD4(+)、CD8(+)、CD68(+)和CD163(+)细胞。有趣的是，这些细胞含有颗粒溶素(+) T细胞，且缺乏Foxp3(高+)调节性T细胞。此外，巨噬细胞主要为CD163(+)，这表明交替活化的巨噬细胞是GF的主要成分之一。总之，目前的数据揭示了构成肉芽肿的细胞以及外用他克莫司治疗GF的可能机制。
