Schiffman S S, Clark C M, Warwick Z S
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710.
Neurobiol Aging. 1990 Nov-Dec;11(6):597-600. doi: 10.1016/0197-4580(90)90023-s.
Significant losses in the ability to detect the taste of glutamic acid and to recognize odorants were found in demented patients when compared with age-matched controls. These losses were not specific to patients with Alzheimer's disease (AD) but were also found in demented patients without AD. Detection thresholds for bitter-tasting quinine HCl were not higher in demented patients than in age-matched controls but were higher than thresholds in young subjects. These data suggest that losses in taste in demented patients may vary with the chemical structure of the tastant. The degree of loss in the ability to recognize odorants was greater in patients with a family history of senile dementia.
与年龄匹配的对照组相比，痴呆患者在检测谷氨酸味道和识别气味剂的能力上出现了显著下降。这些下降并非阿尔茨海默病（AD）患者所特有，在非AD痴呆患者中也有发现。痴呆患者中苦味盐酸奎宁的检测阈值并不高于年龄匹配的对照组，但高于年轻受试者的阈值。这些数据表明，痴呆患者味觉的丧失可能因味觉物质的化学结构而异。有老年痴呆家族史的患者识别气味剂能力的丧失程度更大。
