Smell and Taste Clinic, Department of Otorhinolaryngology, Technical University, Fetscherstr. 74, 01307, Dresden, Germany.
J Neurol. 2010 Feb;257(2):238-46. doi: 10.1007/s00415-009-5300-6. Epub 2009 Sep 1.
In this prospective study we investigated the quantitative and qualitative taste function of patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). 29 healthy, elderly subjects, 29 MCI and 30 AD patients were tested using a validated taste test, the "taste strips". Additionally, odor identification, odor discrimination, odor threshold, the mini-mental state examination (MMSE) and Apo E epsilon 4 status were examined. Regarding taste, there was a significant reduction of total taste scores and also the score for individual tastes on either side of the tongue between controls and MCI/AD patients. There was no significant difference in the taste scores between MCI and AD patients. A taste test may be a useful procedure for differentiating between healthy subjects and patients with MCI/AD in a clinical context. For diagnosing MCI versus AD, further tests such as smell test, MMSE, Apo E epsilon 4 status, FDG-PET and MRI appear to be useful.
在这项前瞻性研究中，我们调查了轻度认知障碍（MCI）和阿尔茨海默病（AD）患者的定量和定性味觉功能。使用经过验证的味觉测试“味觉条”对 29 名健康的老年受试者、29 名 MCI 和 30 名 AD 患者进行了测试。此外，还检查了嗅觉识别、嗅觉辨别、嗅觉阈值、简易精神状态检查（MMSE）和 Apo E ε4 状态。关于味觉，与对照组和 MCI/AD 患者相比，总味觉评分以及舌两侧各味觉的评分均显著降低。MCI 和 AD 患者之间的味觉评分无显著差异。味觉测试可能是在临床环境中区分健康受试者和 MCI/AD 患者的有用程序。对于 MCI 与 AD 的诊断，其他测试，如嗅觉测试、MMSE、Apo E ε4 状态、FDG-PET 和 MRI，似乎更为有用。
