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人体研究性近红外荧光淋巴成像的自动化分析

Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans.

作者信息

Zhang Jingdan, Zhou Shaohua Kevin, Xiang Xiaoyan, Bautista Merrick L, Niccum Blake A, Dickinson Gabriel S, Tan I-Chih, Chan Wenyaw, Sevick-Muraca Eva M, Rasmussen John C

出版信息

Biomed Opt Express. 2012 Jul 1;3(7):1713-23. doi: 10.1364/BOE.3.001713. Epub 2012 Jun 22.

DOI:10.1364/BOE.3.001713
PMID:22808440
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3395493/
Abstract

ALFIA (Automated Lymphatic Function Imaging Analysis), an algorithm providing quantitative analysis of investigational near-infrared fluorescence lymphatic images, is described. Images from nine human subjects were analyzed for apparent lymphatic propagation velocities and propulsion periods using manual analysis and ALFIA. While lymphatic propulsion was more easily detected using ALFIA than with manual analysis, statistical analyses indicate no significant difference in the apparent lymphatic velocities although ALFIA tended to calculate longer propulsion periods. With the base ALFIA algorithms validated, further automation can now proceed to provide a clinically relevant analytic tool for quantitatively assessing lymphatic function in humans.

摘要

描述了一种名为ALFIA（自动淋巴功能成像分析）的算法，它可对研究用近红外荧光淋巴图像进行定量分析。使用手动分析和ALFIA对9名人类受试者的图像进行了分析，以确定表观淋巴传播速度和推进期。虽然使用ALFIA比手动分析更容易检测到淋巴推进，但统计分析表明，尽管ALFIA倾向于计算出更长的推进期，但表观淋巴速度并无显著差异。随着基础ALFIA算法得到验证，现在可以进一步实现自动化，以提供一种临床上相关的分析工具，用于定量评估人类的淋巴功能。

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