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大鼠腰段节前和节后血管运动交感神经元的呼吸调制

Respiratory modulation of pre- and postganglionic lumbar vasomotor sympathetic neurons in the rat.

作者信息

Darnall R A, Guyenet P

机构信息

Department of Pediatrics, University of Virginia School of Medicine, Charlottesville.

出版信息

Neurosci Lett. 1990 Nov 13;119(2):148-52. doi: 10.1016/0304-3940(90)90820-y.

DOI:10.1016/0304-3940(90)90820-y
PMID:2280886
Abstract

The respiratory contribution to the activity of lumbar vasomotor pre- and postganglionic neurons was compared with previously reported respiratory patterns in the activity of neurons in the rostral ventrolateral medulla (RVLM-SE). Two patterns of respiratory modulation were observed characterized by (1) a depression of activity during inspiration and a postinspiratory peak (n = 19), and (2) a peak of activity during inspiration (n = 3). These patterns were similar to those previously reported in RVLM-SE neurons. The latency from the phrenic burst to the onset of respiratory modulation was consistent with the conduction time from the RVLM to the sympathetic chain. This suggests that respiratory modulation observed in lumbar sympathetic activity originates, in part, in RVLM-SE neurons.

摘要

将腰段血管运动节前和节后神经元活动的呼吸作用与先前报道的延髓头端腹外侧区(RVLM - SE)神经元活动的呼吸模式进行了比较。观察到两种呼吸调制模式,其特征为:(1)吸气期活动受抑制且吸气后出现峰值(n = 19),以及(2)吸气期出现活动峰值(n = 3)。这些模式与先前在RVLM - SE神经元中报道的模式相似。从膈神经爆发到呼吸调制开始的潜伏期与从RVLM到交感神经链的传导时间一致。这表明在腰段交感神经活动中观察到的呼吸调制部分源自RVLM - SE神经元。

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