Centre for Cellular and Molecular Biology, Habsiguda, Uppal Road Hyderabad-500 007 Andhra Pradesh, India.
Expert Rev Proteomics. 2012 Jun;9(3):249-65. doi: 10.1586/epr.12.25.
Proteomic approaches have advanced clinical research towards more reliable, sensitive and specific biological diagnostic markers for diseases. Mood disorders are most difficult to diagnose and very much prevalent in society; hence, their proper diagnosis becomes essential. Despite tremendous research efforts to dissect the neurobiological basis of psychiatric disorders, the diagnosis and evaluation for such diseases is still poor. Biomarker discovery in psychiatry research has been accelerated by proteomic technologies, accepting the challenges in order to meet disease state-related investigations. Proteomics-based research for disease-specific protein signatures is expected to give a new direction in psychiatry research. Therefore, this may become a more powerful tool to predict the development, course and outcome of the disease towards personalized psychiatric ailments. The review discusses the role of proteomics in elucidating mechanisms of psychiatric disorders, current status, prospects, limitations and new possibilities towards a strong diagnostic tool in the clinical laboratory.
蛋白质组学方法已经推动了临床研究，使其朝着更可靠、更敏感和更特异的疾病生物诊断标志物方向发展。情绪障碍是最难诊断的，在社会中也非常普遍；因此，对其进行正确诊断变得至关重要。尽管在剖析精神疾病的神经生物学基础方面付出了巨大的研究努力，但对这类疾病的诊断和评估仍然很差。蛋白质组学技术加速了精神病学研究中的生物标志物发现，接受挑战以满足与疾病状态相关的研究。基于蛋白质组学的疾病特异性蛋白质特征研究有望为精神病学研究指明新的方向。因此，它可能成为预测疾病发展、病程和结局的更有力工具，从而实现针对个体精神疾病的精准医疗。本文综述了蛋白质组学在阐明精神疾病发病机制中的作用、当前的状况、前景、局限性和新的可能性，以使其成为临床实验室中的一种强有力的诊断工具。
