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由于β受体阻滞剂引起的扁平苔藓样药物疹:病例报告及文献复习。

Lichen planus-like drug eruptions due to β-blockers: a case report and literature review.

机构信息

Department of Dermatology, Westmead Hospital, Westmead, NSW, Australia.

出版信息

Am J Clin Dermatol. 2012 Dec 1;13(6):417-21. doi: 10.2165/11634590-000000000-00000.

Abstract

Lichen planus-like drug eruptions (LDE) can appear similar or identical to idiopathic lichen planus. We present a 45-year-old man with a widespread, violaceous, papular, generalized exanthema with histologic features of a lichenoid reaction, which subsequently resolved with the cessation of labetatol. We found 29 cases of previously reported β-adrenoceptor antagonist (β-blocker)-associated LDE. This is a relatively rare complication that may present as classic lichenoid papules indistinguishable from lichen planus and has a predilection for the limbs, chest, back, and oral mucosa. Histologically, there is a lichenoid infiltrate often with eosinophils. LDE may be due to drug cross-reactivity or as a result of a suppressed skin adrenergic system. Multiple potential medications in case studies and the inability to differentiate LDE from idiopathic lichen planus in cross-sectional association studies make any conclusive analysis difficult.

摘要

扁平苔藓样药物疹(LDE)可能与特发性扁平苔藓相似或相同。我们报告了一名 45 岁男性,其广泛出现紫红色丘疹性泛发性皮疹,组织学特征为苔藓样反应,随后停用拉贝他洛尔后消退。我们发现了 29 例先前报道的β-肾上腺素能受体拮抗剂(β 阻滞剂)相关的 LDE。这是一种相对罕见的并发症,可能表现为与扁平苔藓无法区分的典型苔藓样丘疹,并且倾向于发生在四肢、胸部、背部和口腔黏膜。组织学上,常有苔藓样浸润,常伴有嗜酸性粒细胞。LDE 可能是由于药物交叉反应,或由于皮肤肾上腺素能系统受到抑制所致。在病例研究中,多种潜在的药物,以及在横断面关联研究中无法将 LDE 与特发性扁平苔藓区分开来,使得任何结论性分析都变得困难。

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