Merk H F, Vanstreels L, Megahed M
Klinik für Dermatologie & Allergologie, RWTH Aachen University, Aachen, Deutschland.
Hautarzt. 2018 Feb;69(2):116-120. doi: 10.1007/s00105-017-4117-y.
Lichenoid drug reactions are rare compared to typical morbilliform drug exanthema or urticaria. They are associated with specific drugs or drug families like gold, antimalarial drugs, β‑blockers and angiotensin-converting-enzyme inhibitors. Recent observations included associations with novel drugs such as biologics (e. g. tumour necrosis factor antagonists) and immune checkpoint inhibitors (anti-programme cell death protein 1 antibodies). Lichenoid drug reactions most often resemble lichen planus mainly in areas of ultraviolet-light exposed skin, but also mucosal lichen planus and even bullous lesions may occur.
与典型的麻疹样药疹或荨麻疹相比，苔藓样药物反应较为罕见。它们与特定药物或药物类别有关，如金制剂、抗疟药、β受体阻滞剂和血管紧张素转换酶抑制剂。最近的观察发现还包括与新型药物的关联，如生物制剂（如肿瘤坏死因子拮抗剂）和免疫检查点抑制剂（抗程序性细胞死亡蛋白1抗体）。苔藓样药物反应最常主要在暴露于紫外线的皮肤区域类似扁平苔藓，但也可能出现黏膜扁平苔藓甚至大疱性病变。
