Laboratório de Microbiologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira n.° 228, 4050-313 Porto, Portugal.
Biochem Biophys Res Commun. 2012 Aug 10;424(4):777-80. doi: 10.1016/j.bbrc.2012.07.034. Epub 2012 Jul 15.
Human noroviruses are the primary cause of foodborne gastroenteritis. Potent and safe inhibitors are needed for the treatment/prophylaxis of norovirus infections. We demonstrate that Favipiravir [T-705, a drug in advanced clinical development for the treatment of infections with the influenza virus] inhibits in vitro murine norovirus replication. Time-of-drug addition studies reveal that T-705 exerts its activity at a time-point that coincides with onset of viral RNA synthesis, which is in line with the viral polymerase as the presumed target.
人类诺如病毒是食源性胃肠炎的主要病原体。因此，需要开发有效且安全的抑制剂来治疗/预防诺如病毒感染。本研究证明，法匹拉韦（T-705，一种用于治疗流感病毒感染的临床前药物）可抑制体外鼠诺如病毒复制。药物加入时间研究表明，T-705 的作用时间点与病毒 RNA 合成起始时间一致，这与聚合酶作为假定靶标一致。
