Feng Bing-Feng, Zhu Kong-Rong
Departments of Pediatrics, Maternity and Child Care Centers of Linyi, Linyi, Shandong 276001, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2012 Jul;14(7):515-7.
To study serum ferritin and neuron-specific enolase (NSE) levels in children with hand-foot-mouth disease (HFMD) complicated by acute viral encephalitis and their clinical significance.
Serum levels of ferritin and NSE were measured using ELISA and electrochemical luminescence in 20 children with HFMD complicated by viral encephalitis (encephalitis group), 20 children with HFMD only (simple HFMD group) and 20 healthy children (control group).
Serum levels of ferritin in the encephalitis group (212 ± 71 μg/L) were significantly higher than in the simple HFMD group (85 ± 18 μg/L) and control group (70 ± 15 μg/L) (P<0.01). Serum levels of NSE in the encephalitis group (8.6 ± 2.6 μg/L) were also significantly higher than in the simple HFMD group (6.0 ± 1.3 μg/L) and control group (5.6 ± 1.8 μg/L) (P<0.01). Significantly decreased serum ferritin (126 ± 37 μg/L) and NSE levels (6.8 ± 1.9 μg/L) were found in the encephalitis group (P<0.01) after treatment.
Serum levels of ferritin and NSE in children with HFMD complicated by acute viral encephalitis increase, suggesting that serum ferritin and NSE measurement is useful in the early diagnosis of HFMD complicated by acute viral encephalitis.
研究手足口病（HFMD）合并急性病毒性脑炎患儿的血清铁蛋白和神经元特异性烯醇化酶（NSE）水平及其临床意义。
采用酶联免疫吸附测定法（ELISA）和电化学发光法检测20例手足口病合并病毒性脑炎患儿（脑炎组）、20例单纯手足口病患儿（单纯HFMD组）和20例健康儿童（对照组）的血清铁蛋白和NSE水平。
脑炎组血清铁蛋白水平（212±71μg/L）显著高于单纯HFMD组（85±18μg/L）和对照组（70±15μg/L）（P<0.01）。脑炎组血清NSE水平（8.6±2.6μg/L）也显著高于单纯HFMD组（6.0±1.3μg/L）和对照组（5.6±1.8μg/L）（P<0.01）。治疗后，脑炎组血清铁蛋白水平（126±37μg/L）和NSE水平（6.8±1.9μg/L）显著降低（P<0.01）。
手足口病合并急性病毒性脑炎患儿的血清铁蛋白和NSE水平升高，提示检测血清铁蛋白和NSE有助于手足口病合并急性病毒性脑炎的早期诊断。
