Nofer Institute of Occupational Medicine, Department of Chemical Safety, st. Teresy str. 8, 91-348 Lodz, Poland.
Nofer Institute of Occupational Medicine, Department of Chemical Safety, st. Teresy str. 8, 91-348 Lodz, Poland.
Environ Toxicol Pharmacol. 2012 Sep;34(2):512-518. doi: 10.1016/j.etap.2012.06.006. Epub 2012 Jun 30.
The aim of this study was to develop an optimal strategy for the assessment of inhalation exposure to isocyanates such as TDI and MDI in the production of polyurethane foam by integration of theoretical and experimental data. ECETOC TRA and EASE predictive models were used to determine the estimated levels of exposure to isocyanates. The results of our study suggest that both applications EASE and ECETOC TRA can be used as a screening 1st Tier tool in this case study. PROC12 ECETOC TRA category can be linked to exposure on TDI during polyurethane foam manufacturing because it is working properly and exceeds 90th percentile measured concentration with factor 3 and the maximum measured value with factor 1, 5. The value estimated by using category PROC2 is underestimated so this category should not be linked to this scenario. At the same time, the applications of EASE overstate the expected concentrations although the scenario "Use in closed process" seems to underestimate the exposure at the "lower end". For MDI the both models estimate exposure in a conservative manner.
本研究旨在通过整合理论和实验数据，为评估生产聚氨酯泡沫过程中异氰酸酯（如 TDI 和 MDI）的吸入暴露，制定最佳策略。ECETOC TRA 和 EASE 预测模型被用于确定异氰酸酯的预估暴露水平。研究结果表明，在这种情况下，EASE 和 ECETOC TRA 这两种应用都可以用作筛选的第一层工具。PROC12 ECETOC TRA 类别可与 TDI 在制造聚氨酯泡沫过程中的暴露相关联，因为它运行良好，超过 90 百分位测量浓度的 3 倍和 1.5 倍的最大测量值。使用类别 PROC2 估计的值被低估，因此不应将此类别与此情况相关联。同时，尽管场景“在封闭过程中使用”似乎低估了“低端”的暴露，但 EASE 的应用却夸大了预期浓度。对于 MDI，这两个模型都以保守的方式估计暴露。
