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一项为期六个月的干预措施,使用了两种不同类型的强化微量营养素的补充食品,对越南婴儿的线性和体重增长产生了明显的短期和长期影响。

A six-month intervention with two different types of micronutrient-fortified complementary foods had distinct short- and long-term effects on linear and ponderal growth of Vietnamese infants.

机构信息

Hanoi Medical University, Hanoi, Vietnam.

出版信息

J Nutr. 2012 Sep;142(9):1735-40. doi: 10.3945/jn.111.154211. Epub 2012 Jul 18.

DOI:10.3945/jn.111.154211
PMID:22810985
Abstract

Traditional complementary foods (CF) with a low nutrient density have been implicated in growth faltering, stunting, and other adverse outcomes in children. The efficacy of 2 types of locally produced, micronutrient-fortified CF to prevent stunting of infants living in rural Vietnam was evaluated. In a village-randomized controlled study, 426 infants, 5 mo of age, received for 6 mo a fortified CF, either as an instant flour (FF) or a food complement (FC) in village canteens, or traditional CF at home (C). After 6 mo of intervention, weight, length, length-for-age Z-score (LAZ) and weight-for-age Z-score were greater in the 2 intervention groups compared with the C group, with an estimated effect of +0.22 LAZ for the FF group and +0.21 LAZ for the FC group. At the last follow-up, 18 mo after the intervention, there was no significant difference in height-for-age Z-score (HAZ) between the groups, even though the HAZ in the FF group was 0.17 greater than that in the C group (P = 0.18). In contrast, the weight-for-height Z-score and BMI Z-score, indices of ponderal growth, were greater in the FF group (-0.49 and -0.26, respectively) than in the FC group (-0.73 and -0.49, respectively), with Z-scores in the C group intermediate and not significantly different from the others. This study shows that regular provision of locally produced CF fortified with micronutrients partly stopped growth faltering in Vietnamese infants, with differential effects on long-term length and ponderal growth. Providing only micronutrients instead of a complete array of nutrients might result in only short-term length growth benefits.

摘要

传统的低营养密度补充食品(CF)与儿童生长迟缓、发育不良和其他不良后果有关。评估了 2 种本地生产的、富含微量营养素的 CF 对预防生活在越南农村的婴儿发育迟缓的效果。在一项村庄随机对照研究中,426 名 5 月龄的婴儿在村庄食堂接受了 6 个月的强化 CF,分别是速溶面粉(FF)或食物补充剂(FC),或在家中食用传统 CF(C)。干预 6 个月后,与 C 组相比,2 个干预组的体重、身长、身长年龄 Z 评分(LAZ)和体重年龄 Z 评分均更高,FF 组的估计效果为+0.22 LAZ,FC 组为+0.21 LAZ。在最后一次随访时,即干预 18 个月后,各组之间的身高年龄 Z 评分(HAZ)没有显著差异,尽管 FF 组的 HAZ 比 C 组高 0.17(P=0.18)。相比之下,FF 组的体重身高 Z 评分和 BMI Z 评分(衡量身体生长的指数)分别比 FC 组高(分别为-0.49 和-0.26),C 组的 Z 评分居中,与其他组无显著差异。本研究表明,定期提供本地生产的、富含微量营养素的 CF 可部分阻止越南婴儿的生长迟缓,对长期身长和身体生长的影响不同。仅提供微量营养素而不是完整的营养素可能只会带来短期的身长生长益处。

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