Javan Roghayeh, Kooshki Akram, Afzalaghaee Monavvar, Aldaghi Mitra, Yousefi Mahdi
MD-PhD of Persian Medicine, Assistant Professor, Traditional and Complementary Medicine Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Student Research Committee, Department of Persian Medicine, Faculty of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Electron Physician. 2017 Dec 25;9(12):6078-6086. doi: 10.19082/6078. eCollection 2017 Dec.
Despite the decreasing rate of under nutrition children in recent years overall, the negative affect in growth and development make it as a main concern in the world. Applying an available and appropriate supplementary food is a major approach in treating children with Moderate Acute Malnutrition (MAM).
To compare the effectiveness of a new supplementary blended flour (containing chickpea, rice, wheat and barley, named Shadameen) in combination with multivitamin/mineral supplement and nutritional counseling versus multivitamin/mineral supplement and nutritional counseling alone, in the treatment of children with MAM.
This randomized controlled trial study was conducted at Heshmatiyeh Hospital in Sabzevar city in Iran, from January 2016 to December 2016. Seventy infants, aged 9 to 24 months with MAM who were referred from urban health centers to the hospital clinic were included. They were randomly assigned to receive, for about 3 months, either multivitamin / mineral supplement and nutritional counseling alone or in combination with an extra supplementary blended food. We analyzed weight, length, weight for length Z score (WLZ), weight for age Z score (WAZ) and length for weight Z score (LAZ), along with recovery rate and adverse events among the two groups. The data were analyzed using SPSS version 16. We used statistics, Chi-square, independent t-test, and Fisher's exact test for the analyses of primary and secondary outcomes.
The food supplementation infant's mean weight and WLZ and WAZ were greater compared with the other group (0.81±0.29 gr and 0.55±0.33 gr, p=0.002), (0.36±0.36 and 0.02±0.52, p=0.003), (0.40±0.33 and 0.09±0.37, p=0.001). The recovery rate in the food supplemented group was significantly higher than the other group (68.4%, 31.6%, p=0.001). No adverse reactions were observed. There were no significant differences in LAZ at the end of the study between the two groups (p=0.53).
This study showed that Shadameen in combination with multivitamin/mineral and counselling therapy can be more effective in decreasing the wasting rate of children with MAM than vitamin/mineral and counseling therapy alone.
The trial was registered at the Iranian Registry of Clinical Trials (http://www.irct.ir) with the Irct ID: IRCT2015040921670N1.
This study was financially supported by the vice chancellor for research office, Mashhad University of Medical Sciences.
尽管近年来儿童营养不良率总体呈下降趋势，但生长发育方面的负面影响使其仍成为全球主要关注问题。应用有效且合适的补充食品是治疗中度急性营养不良（MAM）儿童的主要方法。
比较一种新型补充混合面粉（含鹰嘴豆、大米、小麦和大麦，名为Shadameen）联合多种维生素/矿物质补充剂及营养咨询与单纯多种维生素/矿物质补充剂及营养咨询在治疗MAM儿童中的效果。
本随机对照试验于2016年1月至2016年12月在伊朗萨卜泽瓦尔市的赫什马蒂耶医院进行。纳入70名年龄在9至24个月的MAM婴儿，他们从城市健康中心转诊至医院门诊。将他们随机分配，接受约3个月的单纯多种维生素/矿物质补充剂及营养咨询或联合额外的补充混合食品。我们分析了两组的体重、身长、身长别体重Z评分（WLZ）、年龄别体重Z评分（WAZ）和体重别身长Z评分（LAZ），以及恢复率和不良事件。数据使用SPSS 16版进行分析。我们使用统计学方法、卡方检验、独立t检验和Fisher精确检验来分析主要和次要结局。
与另一组相比，补充食品组婴儿的平均体重、WLZ和WAZ更高（分别为0.81±0.29克和0.55±0.29克，p = 0.002），（0.36±0.36和0.02±0.52，p = 0.003），（0.40±0.33和0.09±0.37，p = 0.001）。补充食品组的恢复率显著高于另一组（68.4%，31.6%，p = 0.001）。未观察到不良反应。研究结束时两组的LAZ无显著差异（p = 0.53）。
本研究表明，Shadameen联合多种维生素/矿物质及咨询疗法在降低MAM儿童消瘦率方面比单纯维生素/矿物质及咨询疗法更有效。
该试验在伊朗临床试验注册中心（http://www.irct.ir）注册，注册号为：IRCT2015040921670N1。
本研究由马什哈德医科大学研究副校长办公室提供资金支持。
