Veeranna Vikas, Zalawadiya Sandip K, Panaich Sidakpal S, Ramesh Krithi, Afonso Luis
Division of Cardiology, Department of Internal Medicine, Wayne State University, Detroit Medical Center, Detroit, Mich., USA.
Cardiology. 2012;122(2):129-32. doi: 10.1159/000339225. Epub 2012 Jul 19.
Red cell distribution width (RDW) and hemoglobin A1c (HbA1c) are both known to be predictive of future cardiovascular disease (CVD).
We hypothesized that RDW would be associated with HbA1c in adults without diabetes independent of fasting blood glucose (FBG).
This cross-sectional study included 15,343 nondiabetic adults, free of CVD, enrolled in NHANES 1999-2008. Adjusted means of RDW were calculated across HbA1c categories for the overall population. Multivariable regression analyses were performed analyzing the association between RDW and HbA1c for individuals with available data on FBG (n = 7,454).
RDW significantly correlated with HbA1c (r = 0.27, p < 0.001; n = 15,343), with a gradual increase in adjusted mean RDW across HbA1c categories (12.59% ± 0.02% in the group with HbA1c ≤4.8% vs. 12.92% ± 0.02% in the group with HbA1c >5.8%, p < 0.001 for trend). In regression analyses, RDW independently predicted HbA1c (β-coefficient 0.034, 95% CI 0.026-0.042, p < 0.001).
RDW significantly predicts HbA1c independent of FBG in healthy nondiabetic adults, suggesting the possibility of chronic hyperglycemia mediating the association between RDW and CVD.
已知红细胞分布宽度（RDW）和糖化血红蛋白A1c（HbA1c）均可预测未来心血管疾病（CVD）。
我们假设在无糖尿病的成年人中，RDW与HbA1c相关，且独立于空腹血糖（FBG）。
这项横断面研究纳入了1999 - 2008年美国国家健康与营养检查调查（NHANES）中15343名无CVD的非糖尿病成年人。计算了总体人群中各HbA1c类别下RDW的校正均值。对有FBG可用数据的个体（n = 7454）进行了多变量回归分析，以分析RDW与HbA1c之间的关联。
RDW与HbA1c显著相关（r = 0.27，p < 0.001；n = 15343），各HbA1c类别下校正后的平均RDW逐渐增加（HbA1c≤4.8%组为12.59%±0.02%，HbA1c>5.8%组为12.92%±0.02%，趋势p < 0.001）。在回归分析中，RDW可独立预测HbA1c（β系数0.034，95%CI 0.026 - 0.042，p < 0.001）。
在健康的非糖尿病成年人中，RDW可独立于FBG显著预测HbA1c，提示慢性高血糖可能介导了RDW与CVD之间的关联。
