成人隐匿性自身免疫性糖尿病患者红细胞分布宽度与胰岛β细胞功能指标的关系。

The relationship between red blood cell distribution width and islet β-cell function indexes in patients with latent autoimmune diabetes in adults.

机构信息

1Department of Endocrinology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China.

出版信息

BMC Endocr Disord. 2023 Aug 24;23(1):180. doi: 10.1186/s12902-023-01435-x.

DOI:10.1186/s12902-023-01435-x

PMID:37620783

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10463511/

Abstract

AIMS

The objective of this study is to explore the relationship between red blood cell distribution and islet β-cell function indexes in patients with Latent Autoimmune Diabetes in Adults.

METHODS

A total of 487 LADA patients were enrolled in this cross-sectional study. Patients were divided into three groups according to RDW tertiles. Clinical and laboratory measurements of age, height, weight, duration of diabetes, blood pressure, RDW, glycosylated hemoglobin A1c (HbA1c), C-peptide and blood lipids were performed. Homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment of β-cell function (HOMA-β) were assessed using homeostasis model assessment (HOMA) based on fasting blood glucose (FBG) and fasting C-peptide index (FCP). Correlations and multiple linear regressions were implemented to determine the association of RDW and islet function indexes.

RESULTS

As the increase of serum RDW level, the presence of β-cell secretion increased(P < 0.05). Correlation analysis indicated that there were significant correlations between RDW and male sex, age, duration, TG, Cr, FCP, and HOMA-β in all subjects. Multiple linear regressions indicated that RDW was significantly correlated with HOMA-β in the total population in both unadjusted and adjusted analysis. This finding could be reproduced in the subgroup of low GAD titers for HOMA-β. RDW were significantly associated with HbA1c in LADA patients with high GAD titers, but the correlation was not found in subgroup with low GAD titers in either unadjusted analyses or adjusted analysis.

CONCLUSIONS

RDW is associated with β-cell function assessed by HOMA-β after adjusting for covariates in LADA patients with low GAD titers.

摘要

目的

本研究旨在探讨成人隐匿性自身免疫性糖尿病（LADA）患者红细胞分布宽度（RDW）与胰岛β细胞功能指标的关系。

方法

本横断面研究纳入了 487 例 LADA 患者。根据 RDW 三分位将患者分为三组。对患者的年龄、身高、体重、糖尿病病程、血压、RDW、糖化血红蛋白 A1c（HbA1c）、C 肽和血脂等临床和实验室指标进行检测。采用基于空腹血糖（FBG）和空腹 C 肽指数（FCP）的稳态模型评估胰岛素抵抗（HOMA-IR）和β细胞功能（HOMA-β），评估稳态模型评估（HOMA）。采用相关分析和多元线性回归确定 RDW 与胰岛功能指标的关系。

结果

随着血清 RDW 水平的升高，β细胞分泌功能增加（P<0.05）。相关性分析表明，在所有受试者中，RDW 与性别、年龄、病程、TG、Cr、FCP 和 HOMA-β 均呈显著相关。多元线性回归分析表明，在未校正和校正分析中，RDW 与总人群的 HOMA-β 均呈显著相关。这一发现可在低 GAD 滴度的 HOMA-β 亚组中重现。RDW 与高 GAD 滴度的 LADA 患者的 HbA1c 显著相关，但在未校正分析或校正分析中，在低 GAD 滴度的亚组中均未发现相关性。