Kiran Challa, Deepika Ponnala
Centre for Cellular and Molecular Biology, India.
Zhongguo Fei Ai Za Zhi. 2012 Jul;15(7):429-34. doi: 10.3779/j.issn.1009-3419.2012.07.07.
MicroRNAs (miRNAs) are a class of non-coding RNAs that hybridize to mRNAs and induce either translation repression or mRNA cleavage. Recently, it has been reported that miRNAs could possibly play a critical role in cellular processes like regulation of cell growth, differentiation, and apoptosis, emphasizing their role in tumorigenesis. Likewise, several miRNA's are involved in lung cancer tumorigenesis. The present review puts forth a database of human miRNA's involved in lung cancer along with their target genes. It also provides sequences of miRNA's and their chromosomal locations retrieved from different databases like microCosm (218 microRNAs), PhenomiR (293 microRNAs), and mir2Disease (90 microRNAs) and target gene information such as the pathways like cell cycle regulation, angiogenesis, apoptosis etc. Though miRNA's are still to be explored, they hold a promise as therapeutic targets and diagnostic markers of cancer.
微小RNA（miRNA）是一类非编码RNA，可与信使核糖核酸（mRNA）杂交，并诱导翻译抑制或mRNA裂解。最近，有报道称，miRNA可能在细胞生长、分化和凋亡调控等细胞过程中发挥关键作用，凸显了它们在肿瘤发生中的作用。同样，几种miRNA也参与肺癌的发生。本综述提出了一个涉及肺癌的人类miRNA及其靶基因的数据库。它还提供了从不同数据库（如microCosm（218个微小RNA）、PhenomiR（293个微小RNA）和mir2Disease（90个微小RNA））检索到的miRNA序列及其染色体位置，以及靶基因信息，如细胞周期调控、血管生成、凋亡等途径。尽管miRNA仍有待探索，但它们有望成为癌症的治疗靶点和诊断标志物。
