Institute for Bioinformatics and Systems Biology (MIPS), Helmholtz Center Munich - German Research Center for Environmental Health (GmbH), Ingolstädter Landstrasse 1, D-85764 Neuherberg, Germany.
Genome Biol. 2010 Jan 20;11(1):R6. doi: 10.1186/gb-2010-11-1-r6.
In recent years, microRNAs have been shown to play important roles in physiological as well as malignant processes. The PhenomiR database http://mips.helmholtz-muenchen.de/phenomir provides data from 542 studies that investigate deregulation of microRNA expression in diseases and biological processes as a systematic, manually curated resource. Using the PhenomiR dataset, we could demonstrate that, depending on disease type, independent information from cell culture studies contrasts with conclusions drawn from patient studies.
近年来，研究表明 microRNAs 在生理和恶性过程中都发挥着重要作用。 PhenomiR 数据库 http://mips.helmholtz-muenchen.de/phenomir 提供了 542 项研究的数据，这些研究系统性地、人工地研究了 microRNA 表达在疾病和生物过程中的失调情况。利用 PhenomiR 数据集，我们可以证明，根据疾病类型的不同，来自细胞培养研究的独立信息与从患者研究中得出的结论相矛盾。
