细胞 RNA 解旋酶与 HIV-1：全基因组、蛋白质组学和分子研究的新视角。
Cellular RNA helicases and HIV-1: insights from genome-wide, proteomic, and molecular studies.
机构信息
Molecular Virology Section 1, Laboratory of Molecular, Microbiology, The National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Virus Res. 2013 Feb;171(2):357-65. doi: 10.1016/j.virusres.2012.06.022. Epub 2012 Jul 16.
Abstract
RNA helicases are ubiquitous in plants and animals and function in many cellular processes. Retroviruses, such as human immunodeficiency virus (HIV-1), encode no RNA helicases in their genomes and utilize host cellular RNA helicases at various stages of their life cycle. Here, we briefly summarize the roles RNA helicases play in HIV-1 replication that have been identified recently, in part, through genome-wide screenings, proteomics, and molecular studies. Some of these helicases augment virus propagation while others apparently participate in antiviral defenses against viral replication.
摘要
RNA 解旋酶在动植物中普遍存在，参与多种细胞过程。逆转录病毒，如人类免疫缺陷病毒（HIV-1），在其基因组中不编码 RNA 解旋酶，而是在其生命周期的各个阶段利用宿主细胞 RNA 解旋酶。在这里，我们简要总结了最近通过全基因组筛选、蛋白质组学和分子研究部分确定的 RNA 解旋酶在 HIV-1 复制中所起的作用。其中一些解旋酶增强了病毒的繁殖，而另一些显然参与了抗病毒防御，以对抗病毒复制。
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