HIV DNA疫苗：逐步改进产生显著效果。
HIV DNA Vaccine: Stepwise Improvements Make a Difference.
作者信息
Felber Barbara K, Valentin Antonio, Rosati Margherita, Bergamaschi Cristina, Pavlakis George N
机构信息
Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, USA.
Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, USA.
出版信息
Vaccines (Basel). 2014 May 14;2(2):354-79. doi: 10.3390/vaccines2020354.
Inefficient DNA delivery methods and low expression of plasmid DNA have been major obstacles for the use of plasmid DNA as vaccine for HIV/AIDS. This review describes successful efforts to improve DNA vaccine methodology over the past ~30 years. DNA vaccination, either alone or in combination with other methods, has the potential to be a rapid, safe, and effective vaccine platform against AIDS. Recent clinical trials suggest the feasibility of its translation to the clinic.
低效的DNA递送方法和质粒DNA的低表达一直是将质粒DNA用作HIV/AIDS疫苗的主要障碍。本综述描述了过去约30年中在改进DNA疫苗方法方面所取得的成功努力。DNA疫苗，无论是单独使用还是与其他方法联合使用，都有潜力成为一种针对艾滋病的快速、安全且有效的疫苗平台。最近的临床试验表明了其转化至临床应用的可行性。
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