Advanced Materials Research Chair, Department of Chemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia.
J Sep Sci. 2012 Oct;35(19):2538-43. doi: 10.1002/jssc.201200312. Epub 2012 Jul 20.
Bromate is a byproduct formed as a result of disinfection of bromide-containing source water with ozone or hypochlorite. The International Agency for Research on Cancer has recognized bromate as a possible human carcinogen, thus it is essential to determine in drinking water. Present work highlights a development of sensitive and fast analytical method for bromate determination in drinking water by using ultraperformance liquid chromatography-tandem mass spectrometry. The quality parameters of the developed method were established, obtaining very low limit of detection (0.01 ng/mL), repeatability and reproducibility have been found to be less than 3% in terms of relative standard deviation when analyzing a bromate standard at 0.05 μg/mL with 0.4 min analysis time. Developed method was applied for the analysis of metropolitan and bottled water from Saudi Arabia; 22 samples have been analyzed. Bromate was detected in the metropolitan water samples (from desalinization source) at concentrations ranging between 3.43 and 75.04 ng/mL and in the bottled water samples at concentrations ranging between 2.07 and 21.90 ng/mL. Moreover, in comparison to established analytical methods such as liquid chromatography-tandem mass spectrometry, the proposed method was found to be very sensitive, selective and rapid for the routine analysis of bromate at low level in drinking water.
溴酸盐是一种副产物，在含有溴化物的水源用臭氧或次氯酸盐消毒时形成。国际癌症研究机构已将溴酸盐认定为一种可能的人类致癌物，因此必须在饮用水中进行检测。本工作重点开发了一种超高效液相色谱-串联质谱法，用于饮用水中溴酸盐的灵敏快速分析方法。该方法的质量参数已经建立，当以 0.05μg/mL 的浓度分析 0.01ng/mL 的溴酸盐标准品时，在 0.4 分钟的分析时间内，检测限（0.01ng/mL）非常低，重复性和再现性的相对标准偏差小于 3%。所开发的方法已应用于沙特阿拉伯城市和瓶装水的分析，共分析了 22 个样本。在城市水样（来自海水淡化源）中检测到溴酸盐的浓度范围为 3.43-75.04ng/mL，在瓶装水样中浓度范围为 2.07-21.90ng/mL。此外，与已建立的分析方法（如液相色谱-串联质谱法）相比，该方法在低水平饮用水中对溴酸盐的常规分析具有非常高的灵敏度、选择性和快速性。
