De Lisa Emilia, De Maio Anna, Moroz Leonid L, Moccia Francesco, Mennella Maria Rosaria Faraone, Di Cosmo Anna
Department of Structural and Functional Biology, University of Napoli Federico II, via Cinthia, 80126 Napoli, Italy.
Biol Bull. 2012 Jun;222(3):176-81. doi: 10.1086/BBLv222n3p176.
Recent investigation has focused on the participation of the poly (ADP-ribose) polymerase (PARP) reaction in the invertebrate central nervous system (CNS) during the process of long-term memory (LTM). In this paper, we characterize, localize, and assign a possible role to a cytoplasmic PARP in the brain of . PARP activity was assayed in optic lobes, supraesophageal mass, and optic nerves. The highest levels of enzyme were found in the cytoplasmic fraction. Hyper-activation of the enzyme was detected in brain after visual discrimination training. Finally, cytoplasmic PARP was found to inhibit actin polymerization. We propose that the cytoplasmic PARP plays a role to induce the cytoskeletonal reorganization that occurs during learning-induced neuronal plasticity.
最近的研究集中在聚（ADP - 核糖）聚合酶（PARP）反应在无脊椎动物中枢神经系统（CNS）长期记忆（LTM）过程中的参与情况。在本文中，我们对[某种动物]大脑中的一种细胞质PARP进行了表征、定位并赋予其可能的作用。在视叶、食管上神经节和视神经中检测了PARP活性。酶的最高水平存在于细胞质部分。在视觉辨别训练后的[某种动物]大脑中检测到了该酶的过度激活。最后，发现细胞质PARP抑制肌动蛋白聚合。我们提出细胞质PARP在诱导学习诱导的神经元可塑性过程中发生的细胞骨架重组中发挥作用。
