Shiramizu Bruce, Liang Chin-Yuan, Agsalda-Garcia Melissa, Nagata Ian, Milne Cris, Zhu Xuemei, Killeen Jeffrey, Berry J Michael, Goodman Marc T
University of Hawaii, Hawaii Center of AIDS, Honolulu, HI 96813, USA.
AIDS Res Hum Retroviruses. 2013 Jan;29(1):178-81. doi: 10.1089/AID.2012.0136. Epub 2012 Aug 27.
Human immunodeficiency virus type 1 (HIV)-infected individuals are at risk for anal cancer, which is caused by human papillomavirus (HPV). The relationship between HIV and HPV that leads to anal cancer remains unclear. Recent data, however, suggest that the continued persistence of HIV DNA in patients treated with combined antiretroviral therapy leads to progression of HIV disease and other HIV-associated complications. Therefore, we investigated the relationship among anal low- and high-grade squamous intraepithelial lesions (LGSIL/HGSIL), high-risk HPV genotypes, and high HIV DNA copy numbers. Anal cytology specimens were assayed for HPV genotype and HIV DNA copy number. High-risk HPV genotypes (odds ratio OR: 3.73; 95% confidence interval CI: 1.08-12.91; p=0.04) and high HIV DNA copy numbers (OR(per 100 HIV DNA copies): 1.13; 95% CI: 1.01-1.27, p=0.04) were both associated with LGSIL/HGSIL. When considering both high-risk HPV genotypes and HIV DNA copy numbers in predicting LGSIL/HGSIL, HIV DNA copy number was significant (OR(per 100 HIV DNA copies): 1.09; 95% CI: 0.96-1.23, p=0.04) but not high-risk HPV genotypes (OR: 2.30, p=0.28), which did not change when adjusted for nadir CD4 cell count and HIV RNA levels. The findings warrant further investigation of HIV DNA and its relationship with HPV in LGSIL/HGSIL pathogenesis.
感染1型人类免疫缺陷病毒（HIV）的个体有患肛门癌的风险，肛门癌由人乳头瘤病毒（HPV）引起。导致肛门癌的HIV与HPV之间的关系仍不清楚。然而，最近的数据表明，接受联合抗逆转录病毒治疗的患者中HIV DNA的持续存在会导致HIV疾病进展和其他与HIV相关的并发症。因此，我们研究了肛门低级别和高级别鳞状上皮内病变（LGSIL/HGSIL）、高危HPV基因型和高HIV DNA拷贝数之间的关系。对肛门细胞学标本进行HPV基因型和HIV DNA拷贝数检测。高危HPV基因型（优势比OR：3.73；95%置信区间CI：1.08 - 12.91；p = 0.04）和高HIV DNA拷贝数（每100个HIV DNA拷贝的OR：1.13；95% CI：1.01 - 1.27，p = 0.04）均与LGSIL/HGSIL相关。在预测LGSIL/HGSIL时同时考虑高危HPV基因型和HIV DNA拷贝数，HIV DNA拷贝数具有显著性（每100个HIV DNA拷贝的OR：1.09；95% CI：0.96 - 1.23，p = 0.04），而高危HPV基因型不具有显著性（OR：2.30，p = 0.28），在根据最低点CD4细胞计数和HIV RNA水平进行调整后这一情况未改变。这些发现值得进一步研究HIV DNA及其在LGSIL/HGSIL发病机制中与HPV的关系。
