Azinet LLC, Box 239 Crownsville, MD 21032, USA.
Biochemistry (Mosc). 2012 Jul;77(7):729-32. doi: 10.1134/S000629791207005X.
The programmed vs. non-programmed aging controversy has now existed in some form for at least 150 years. For much of the XX century, it was almost universally believed that evolution theory prohibited programmed (adaptive) aging in mammals and there was little direct experimental or observational evidence favoring it. More recently, multiple new evolutionary mechanics concepts that support programmed aging and steadily increasing direct evidence favoring it overwhelmingly support the existence of programmed aging in humans and other organisms. This issue is important because the different theories suggest very different mechanisms for the aging process that in turn suggest very different paths toward treating and preventing age-related diseases.
程序性衰老与非程序性衰老的争议至少已经存在了 150 年。在 XX 世纪的大部分时间里，人们几乎普遍认为，进化理论禁止哺乳动物发生程序性（适应性）衰老，而且几乎没有直接的实验或观察证据支持这一观点。最近，越来越多的新进化力学概念支持程序性衰老，并且越来越多的直接证据也支持程序性衰老的存在，这些压倒性地支持了程序性衰老在人类和其他生物体中的存在。这个问题很重要，因为不同的理论提出了衰老过程的不同机制，而这些机制反过来又提出了治疗和预防与年龄相关疾病的不同途径。
