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实验进化。

Experimental evolution.

机构信息

Department of Ecology and Evolution, University of Lausanne, CH 1015 Lausanne, Switzerland.

出版信息

Trends Ecol Evol. 2012 Oct;27(10):547-60. doi: 10.1016/j.tree.2012.06.001. Epub 2012 Jul 21.

Abstract

Experimental evolution is the study of evolutionary processes occurring in experimental populations in response to conditions imposed by the experimenter. This research approach is increasingly used to study adaptation, estimate evolutionary parameters, and test diverse evolutionary hypotheses. Long applied in vaccine development, experimental evolution also finds new applications in biotechnology. Recent technological developments provide a path towards detailed understanding of the genomic and molecular basis of experimental evolutionary change, while new findings raise new questions that can be addressed with this approach. However, experimental evolution has important limitations, and the interpretation of results is subject to caveats resulting from small population sizes, limited timescales, the simplified nature of laboratory environments, and, in some cases, the potential to misinterpret the selective forces and other processes at work.

摘要

实验进化是指在实验种群中研究由于实验者施加的条件而发生的进化过程。这种研究方法越来越多地被用于研究适应性、估计进化参数和检验各种进化假说。实验进化在疫苗开发中应用已久,在生物技术中也有新的应用。最近的技术发展为深入了解实验进化变化的基因组和分子基础提供了一条途径,而新的发现提出了可以通过这种方法解决的新问题。然而,实验进化有其重要的局限性,其结果的解释受到一些因素的限制,例如种群规模小、时间尺度有限、实验室环境的简化性质,以及在某些情况下,可能会误解起作用的选择压力和其他过程。

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