Grigor'ev B A
Arkh Patol. 1990;52(10):40-5.
The literature data on primary liver apudomas with the discussion of their histogenesis, structure, endocrine activity and immunohistochemistry, 36 hepato- and cholangiocarcinomas are studied among which a group of poorly differentiated "atypical" tumours (9 cases) is distinguished. Large areas of endocrine-cell differentiation represented by solid, trabecular and alveolar structures consisting of small lymphocytoid cells or big cells with eosinophil cytoplasm and numerous sinusoid vessels were observed in these tumours. Cytoplasm of these cells contained argyrophylic granules in variable quantity. It is suggested that a certain part of primary liver apudomas is mistaking considered as poorly differentiated "atypical" hepato- or cholangiocarcinomas.
关于原发性肝APUD瘤的文献资料，包括对其组织发生、结构、内分泌活性及免疫组织化学的讨论，研究了36例肝细胞癌和胆管癌，其中区分出一组低分化的“非典型”肿瘤（9例）。在这些肿瘤中观察到由小淋巴细胞样细胞或具有嗜酸性细胞质的大细胞以及众多窦状血管组成的实性、小梁状和肺泡状结构所代表的大面积内分泌细胞分化。这些细胞的细胞质中含有数量不等的嗜银颗粒。提示原发性肝APUD瘤的某些部分被错误地认为是低分化的“非典型”肝细胞癌或胆管癌。
