Serezhin B S, Semova N V, Paĭkova L V
Arkh Patol. 1985;47(4):57-60.
A peculiar mammary gland tumour is described. Histological structures typical for apudomas of various level of differentiation were combined in the tumour. Apart from highly differentiated carcinoid-like areas, there were zones of a small-cell carcinoma corresponding to a poorly differentiated variant of apudoma. Deposits of amyloid were found in the tumor stroma, this being non-typical for mammary carcinoma. Amyloid was stained by Congo red and birefringent in a polarizing microscope. When differential diagnostics of mammary gland tumours is made, stromal amyloidosis in parallel to typical histological picture and specific histochemical reactions may play a role of an additional diagnostic symptom.
描述了一种特殊的乳腺肿瘤。肿瘤中合并了不同分化程度的APUD瘤的典型组织结构。除了高分化的类癌样区域外，还有对应于APUD瘤低分化变体的小细胞癌区域。在肿瘤间质中发现了淀粉样沉积物，这在乳腺癌中并不典型。淀粉样物质经刚果红染色后，在偏振显微镜下呈双折射。在进行乳腺肿瘤的鉴别诊断时，与典型组织学图像和特定组织化学反应同时出现的间质淀粉样变可能起到辅助诊断症状的作用。
