Fojtíková Markéta, Stolfa Jirí, Novota Peter, Cejková Pavlína, Dostál Ctibor, Cerná Marie
Institute of Rheumatology, Prague 2, Czech Republic.
Rheumatol Int. 2009 Sep;29(11):1293-9. doi: 10.1007/s00296-009-0847-1. Epub 2009 Jan 28.
Psoriatic arthritis (PsA) is a chronic inflammatory joint disease which affects patients suffering from psoriasis. The genetic background especially the susceptibility loci on the short arm of the chromosome six contribute to PsA development. In our study, we looked for the role of the MICA and HLA-Cw genes polymorphisms in PsA pathogenesis. We investigated 100 PsA patients and 94 healthy Czech individuals. We found an association between HLA-Cw*06 and PsA namely PsA with psoriasis type I (age of psoriasis onset before 40 years) compared to healthy individuals (P (corrected) < 0.05, OR 2.56, CI 95% 1.33-4.76 and P (corrected) = 0.01, OR 3.03, CI 95% 1.53-5.88, respectively). The MICA-A9 allele of the transmembrane microsatelite MICA polymorphism occurred more frequently in PsA with psoriasis type II group (age of psoriasis onset after 40 years) than in controls, 58.6 versus 38.0%, respectively however, this finding did not reach a statistical significance after correction (P (corrected) = 0.085).
银屑病关节炎（PsA）是一种影响银屑病患者的慢性炎症性关节疾病。遗传背景，尤其是6号染色体短臂上的易感基因座，对PsA的发病有影响。在我们的研究中，我们探究了MICA和HLA - Cw基因多态性在PsA发病机制中的作用。我们调查了100例PsA患者和94名健康的捷克人。我们发现HLA - Cw*06与PsA存在关联，即与健康个体相比，I型银屑病相关的PsA（银屑病发病年龄在40岁之前）（校正后P<0.05，OR 2.56，95%CI 1.33 - 4.76；校正后P = 0.01，OR 3.03，95%CI 1.53 - 5.88）。跨膜微卫星MICA多态性的MICA - A9等位基因在II型银屑病相关的PsA组（银屑病发病年龄在40岁之后）中出现的频率高于对照组，分别为58.6%和38.0%，然而，校正后这一发现未达到统计学意义（校正后P = 0.085）。
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