Instituto de Biología Molecular de Barcelona, CSIC, Parc Científic de Barcelona, Spain.
Dev Neurobiol. 2012 Dec;72(12):1471-81. doi: 10.1002/dneu.22015. Epub 2012 Jul 20.
Development of the vertebrate nervous system begins with the acquisition of neural identity from the midline dorsal-ectodermal cells of the gastrulating embryos. The subsequent progressive specification of the neural plate along its anterior-posterior and dorsal-ventral (DV) axes allows the generation of the tremendous variety of neuronal and glial cells that compose the vertebrate central nervous system (CNS). Studies on the development of the spinal cord, the anatomically simplest part of the CNS, have generated most of our current knowledge on the signaling events and the genetic networks that orchestrate the DV patterning of the neural plate. In this review, we discuss the recent advances in our understanding of these events and highlight unresolved questions. We focused our attention on the activity and the integration of the three main instructive cues: Sonic hedgehog, the Wnts and the Bone Morphogenetic Proteins, giving particular attention to the less well understood dorsal signaling events.
脊椎动物神经系统的发育始于原肠胚期中胚层背部外胚层细胞获得神经特征。随后，神经板沿前后轴和背腹轴（DV）的逐步特化，允许产生组成脊椎动物中枢神经系统（CNS）的大量神经元和神经胶质细胞。对脊髓发育的研究，即 CNS 中解剖结构最简单的部分，产生了我们目前对协调神经板 DV 模式形成的信号事件和遗传网络的大部分认识。在这篇综述中，我们讨论了对这些事件的理解的最新进展，并强调了未解决的问题。我们将注意力集中在三个主要指导线索的活性和整合上：Sonic Hedgehog、Wnts 和骨形态发生蛋白，特别关注了解较少的背侧信号事件。
