Dessaud Eric, McMahon Andrew P, Briscoe James
Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK.
Development. 2008 Aug;135(15):2489-503. doi: 10.1242/dev.009324.
Neuronal subtype specification in the vertebrate neural tube is one of the best-studied examples of embryonic pattern formation. Distinct neuronal subtypes are generated in a precise spatial order from progenitor cells according to their location along the anterior-posterior and dorsal-ventral axes. Underpinning this organization is a complex network of multiple extrinsic and intrinsic factors. This review focuses on the molecular mechanisms and general strategies at play in ventral regions of the forming spinal cord, where sonic hedgehog-based morphogen signaling is a key determinant. We discuss recent advances in our understanding of these events and highlight unresolved questions.
脊椎动物神经管中神经元亚型的特化是胚胎模式形成中研究得最为透彻的例子之一。不同的神经元亚型由祖细胞根据其沿前后轴和背腹轴的位置，以精确的空间顺序产生。支撑这种组织的是一个由多种外在和内在因素组成的复杂网络。本综述聚焦于正在形成的脊髓腹侧区域所涉及的分子机制和一般策略，其中基于音猬因子的形态发生素信号是关键决定因素。我们讨论了在理解这些事件方面的最新进展，并突出了尚未解决的问题。
