Yang Junyu, Hao Yang, Xi Jianzhong Jeff
Peking University, Beijing, China.
J Lab Autom. 2013 Feb;18(1):30-3. doi: 10.1177/2211068212453460. Epub 2012 Jul 20.
MicroRNAs (miRNAs) are deregulated in human cancers. A large number of studies have shown that miRNAs play critical roles in tumorigenesis, either as oncogenes or tumor suppressors. This review provides an overview of current research on the roles of miRNA in cancer development. Furthermore, we also discuss the current progress and limitation of therapeutic application of miRNAs in preclinical studies.
微小RNA（miRNA）在人类癌症中表达失调。大量研究表明，miRNA在肿瘤发生过程中发挥着关键作用，既可以作为癌基因，也可以作为肿瘤抑制因子。本综述概述了目前关于miRNA在癌症发展中作用的研究。此外，我们还讨论了miRNA在临床前研究中治疗应用的当前进展和局限性。
