Zikk D, Rapoport Y, Bloom J, Himelfarb M Z
Department of Otorhinolaryngology, Tel Aviv Sourasky Medical Center, Ichilov Hospital, Israel.
Eur Arch Otorhinolaryngol. 1990;248(2):102-4. doi: 10.1007/BF00240230.
The effects on auditory function caused by implantation of the bioactive glass ceramic Ceravital in the middle ear of guinea pigs was investigated. Auditory brain-stem responses (ABR) were used to measure hearing function. A threshold shift due to a conductive hearing loss was observed immediately post-operatively. This threshold shift increased towards the 20th post-operative day and improved thereafter. Surgical manipulation of the middle ear and biochemical reactions between the Ceravital granules and the middle ear wall may have contributed respectively to the immediate and late temporary ABR threshold shift recorded. However, cochlear function was not affected by middle ear implantation of Ceravital. These results correlate well with morphological studies of Ceravital implanted in the middle ear and give further support to the safe use of Ceravital as an implantation material in middle ear reconstructive surgery.
研究了生物活性玻璃陶瓷Ceravital植入豚鼠中耳对听觉功能的影响。采用听性脑干反应（ABR）来测量听力功能。术后立即观察到由于传导性听力损失导致的阈值偏移。该阈值偏移在术后第20天逐渐增加，此后有所改善。中耳的手术操作以及Ceravital颗粒与中耳壁之间的生化反应可能分别导致了记录到的即刻和晚期暂时性ABR阈值偏移。然而，Ceravital植入中耳并未影响耳蜗功能。这些结果与中耳植入Ceravital的形态学研究结果良好相关，并进一步支持了Ceravital作为中耳重建手术植入材料的安全使用。
