蜂蜜对水痘带状疱疹病毒（VZV）的体外抗病毒活性：一项针对带状疱疹潜在治疗方法的转化医学研究。
In vitro antiviral activity of honey against varicella zoster virus (VZV): A translational medicine study for potential remedy for shingles.
作者信息
Shahzad Aamir, Cohrs Randall J
机构信息
Department of Neurology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
出版信息
Transl Biomed. 2012;3(2). doi: 10.3823/434.
Abstract
OBJECTIVES
The aim of this study was to determine the in vitro anti-viral effect of honey on varicella zoster virus. METHODS: Manuka and clover honeys were used at concentrations ranging from 0-6% wt/vol. A clinical VZV isolate was obtained from a zoster vesicle and used at low passage. Various concentrations of manuka and clover honey were added to the tissue culture medium of VZV-infected human malignant melanoma (MeWo) cells. RESULTS: Both types of honey showed antiviral activity against varicella zoster virus with an approximate EC50 = 4.5 % (wt/vol). CONCLUSIONS: Our results showed that honey has significant in vitro anti-VZV activity. As, honey is convenient for skin application, is readily available and inexpensive, honey may be an excellent remedy to treat zoster rash in developing countries where antiviral drugs are expensive or not easily available.
摘要
目的
本研究旨在确定蜂蜜对水痘带状疱疹病毒的体外抗病毒作用。方法：使用麦卢卡蜂蜜和三叶草蜂蜜，浓度范围为0 - 6%（重量/体积）。从带状疱疹水疱中获得临床水痘带状疱疹病毒分离株，并在低传代时使用。将不同浓度的麦卢卡蜂蜜和三叶草蜂蜜添加到感染水痘带状疱疹病毒的人恶性黑色素瘤（MeWo）细胞的组织培养基中。结果：两种类型的蜂蜜均显示出对水痘带状疱疹病毒的抗病毒活性，近似半数有效浓度（EC50）= 4.5%（重量/体积）。结论：我们的结果表明蜂蜜具有显著的体外抗水痘带状疱疹病毒活性。由于蜂蜜便于皮肤应用、容易获得且价格低廉，在抗病毒药物昂贵或不易获得的发展中国家，蜂蜜可能是治疗带状疱疹皮疹的极佳药物。
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