马来西亚霹雳州金宝健康诊所队列中黑皮质素受体4（MC4R）V103I基因变体的患病率及其与肥胖的关联。

Prevalence of melanocortin receptor 4 (MC4R) V103I gene variant and its association with obesity among the Kampar Health Clinic cohort, Perak, Malaysia.

作者信息

Chua H N, Fan S H, Say Y H

机构信息

Universiti Tunku Abdul Rahman, Biomedical Science, Jalan Universiti, Bandar Barat, Kampar, Perak 31900, Malaysia.

出版信息

Med J Malaysia. 2012 Apr;67(2):234-5.

PMID:22822657

Abstract

This study investigated the prevalence of the Melanocortin receptor 4 (MC4R) V1031 gene variant and its association with obesity among a cohort of 254 patients (101 males; 118 obese) attending the Kampar Health Clinic. Genotyping revealed the mutated I allele frequency of 0.02, no homozygous mutated (II), and similar distribution of V and I alleles across BMI groups, genders and ethnic groups. No significant difference was found for the means of anthropometric measurements between alleles. Prevalence of this gene variant among the Malaysian cohort was similar with previous populations (2-4% of mutated allele carrier), but was not associated with obesity.

摘要

本研究调查了金宝健康诊所的254名患者（101名男性；118名肥胖者）队列中黑皮质素受体4（MC4R）V1031基因变体的流行情况及其与肥胖的关联。基因分型显示突变的I等位基因频率为0.02，无纯合突变（II），且V和I等位基因在体重指数组、性别和种族组中的分布相似。等位基因之间的人体测量均值未发现显著差异。该基因变体在马来西亚队列中的流行情况与先前人群相似（突变等位基因携带者占2%-4%），但与肥胖无关。